Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Nataliya Dolgushina

Publications

• Research Article
  Single Nucleotide Polymorphisms of BMP15 are Associated with Poor Ovarian Response in In Vitro Fertilization Programs
  Author(s): Rosa Vanyan, Nataliya Dolgushina, Andrey Donnikov, Ekaterina Shubina, Natalia Usman, Maria Kuznetsova and Gennady Sukhikh Rosa Vanyan, Nataliya Dolgushina, Andrey Donnikov, Ekaterina Shubina, Natalia Usman, Maria Kuznetsova and Gennady Sukhikh
  
  Background: Poor ovarian response represents a major negative contribution to the efficacy of In vitro fertilization programs. It has been shown that specific nucleotide sequence variants of BMP15 gene, which encodes the growth factor specifically expressed by oocytes to regulate follicle development, are related to certain forms of ovarian dysfunction. The aim of the study was to search for novel variants related to poor ovarian response phenotypes by means of exon sequencing, and also to check possible relations of already known BMP15 variants to this particular form of ovarian insufficiency. Methods: A total of 150 patients (65 women with poor ovarian response and 85 women with normal ovarian response as a control group) participated in this retrospective case-control study. All patients received ovarian stimulation according to the proto.. View More»
  DOI: 10.4172/2375-4508.1000159

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