Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Naveen kumar Nagarajan
India
Research Article
Peptidomimetics Based Inhibitor Design for HIV 1 gp120 Attachment Protein
Author(s): Umashankar Vetrivel, Priya Sankar, Naveen kumar Nagarajan and Gurunathan SubramanianUmashankar Vetrivel, Priya Sankar, Naveen kumar Nagarajan and Gurunathan Subramanian
Peptidomimetics is a novel drug designing strategy in which an Insilico inhibitor is designed by mimicking the framework of a short peptide. Novel drug design str ate- gies shall only pave way for developing unique and safer anti-HIV drugs. In the present study, we propose a Peptidomimetics based gp120 attachment inhibitor. I n human biological system, HIV-1 interacts with CD4 r e- ceptor of the host via its surface glycoprotein gp1 20 es- tablishing initial attachment. This protein–protein inter- action interface forms the base to derive an inhibi tor mim- icking backbone of the receptor. The mimicked inhib itor derived in this study is based on the insilico interactions of soluble CD4 (SCD4) (precursor of CD4) with gp120 . The molecular interactions of SCD4 with gp120 were iden- tified by MEDock s.. View More»
DOI:
10.4172/jpb.1000109