Mycobacterial Diseases
Open Access

Neeloffer Mookherjee

Publications

• Research Article
  Frequency of NRAMP1 Gene Polymorphisms among Canadian First Nations Peoples Experiencing Endemic Tuberculosis
  Author(s): Linda A Larcombe, Neeloffer Mookherjee, Andrew M Lodge, Jodie S Brown, Lizette Denechezhe, Peter W Nickerson and Pamela H Orr Linda A Larcombe, Neeloffer Mookherjee, Andrew M Lodge, Jodie S Brown, Lizette Denechezhe, Peter W Nickerson and Pamela H Orr
  
  Objectives: The natural resistance-associated macrophage protein 1 (NRAMP1) regulates susceptibility to infectious and autoimmune diseases. NRAMP1 gene polymorphisms have been implicated in susceptibility to tuberculosis. The frequency of NRAMP1 gene polymorphisms was therefore evaluated in three Manitoba First Nations sub-groups (Dene, Cree, and Saulteaux) with differential but high rates of tuberculosis (636/100,000, 496/100,000, and 0/100,000 respectively). Methods: Venous blood samples were collected from 281 study participants from three First Nations sub-groups (Dene (N=108), Cree (N=41), Saulteaux (N=49)), and a non-indigenous Canadian-born (European-descent) group (N=83). Genomic DNA was extracted and four single nucleotide polymorphisms in the NRAMP1 gene (5′ (GT)n, -274 (C/T), Intron 4 (469+14 G/C), D543N (G/A)) were genotype.. View More»
  DOI: 10.4172/2161-1068.1000193

  Abstract PDF

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