Journal of Drug Metabolism & Toxicology
Open Access

Neha Mathur

Publications

• Research Article
  Pharmacokinetics, Metabolism and Excretion of Hypolipidemic DRUG: 16-Dehydropregnenolone
  Author(s): Pratima Srivastava, Neha Mathur and Ashim GhatakPratima Srivastava, Neha Mathur and Ashim Ghatak
  
  Purpose: 16-dehydropregnenolone/DHP/CDRI-80/574, a new orally effective hypolipidemic agent presently in advanced clinical trials. This paper aims to study the absorption, distribution, metabolism and excretion profiles in order to delineate the possible cause(s) behind low bioavailability of CDRI-80/574 and also strategy to enhance the same. " Methods: Metabolic, Excretion and Pharmacokinetics studies were conducted in the Sprague-Dawley rats. Results: CDRI-80/574 exhibited log D: 4.5, absorption-half-life of 18 min and -constant 0.04/min by closed loop intestinal model in rats, was stable in gastric juice and 30% of RBCs transport/uptake was noted. CDRI-80/574 undergoes rapid metabolism in rat hepatic microsomal fractions; however extra hepatic tissues (intestinal-wall and -microvilli), showed less metabolism. IC5.. View More»
  

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