Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Nelli Akhmatova
I. I. Mechnikov Research Institute of Vaccines and Serums,
Maly Kazenny pereulok 5a, Moscow, 105064
Russian Federation
Research Article
Influence of MNRI on the Immune Status of Children with Down Syndrome
Author(s): Nelli Akhmatova and Elina Akhmatova
Nelli Akhmatova and Elina Akhmatova
The clinical and immunological characteristics of 49 children with Down syndrome were studied. Thirty-four boys and 15 girls between the ages of zero and six years old were observed.
It was revealed that children in the Study Group with Down syndrome developed a greater number of disorders starting at the earliest stages of pregnancy and delivery, such as fetal malnutrition, congenital heart defects, and pathology of vision, than children in the control group (p<0.05). All of the children in the Study Group had allergic reactions and were frequently ill. There was a noticed decrease in the numbers of subpopulations of T-lymphocytes (?D45/CD3), CD3/CD4, CD3/CD8 and the absolute number of B-cells (CD45/CD19), and at IgG pool, indicating a certain deficiency in cell-mediated and humoral immune responses which provides a base for frequent diseases, including bacterial diseases. .. View More»
DOI:
10.4172/2155-9899.1000483