Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ng Kee Kwong F
Royal Brompton and Harefield NHS Trust,
Sydney Street, London
United Kingdom
Research Article
Mitochondrial-Related Gene Expression and Macrophage Signatures in Non-Small Cell Lung Cancer, Including Patients with Emphysema as Co-Morbidity
Author(s): Ng Kee Kwong F, Nicholson AG, Pavlidis S, Adcock IM and Chung KF
Ng Kee Kwong F, Nicholson AG, Pavlidis S, Adcock IM and Chung KF
Objective: Our aim is to determine whether mitochondrial dysfunction is a contributing factor to the increased risk of non-small cell lung carcinoma (NSCLC) in COPD patients.
Methods: The clinical relevance of mitochondrial-related gene expression in lung cancer was determined using transcriptomic data from more than 1000 human NSCLC samples. Immunohistochemistry was then used to study cell type specific expression of the relevant mitochondrial-related protein in normal and cancerous lung tissue. Gene set variation analysis (GSVA) was applied in NSCLC datasets to determine the relative expression of specific macrophage transcriptomic signatures.
Results: The expression of 33 mitochondrial-related genes was correlated with NSCLC patient survival. We studied further the expression of PGAM5 and FUNDC1, which are regulators .. View More»
DOI:
10.4172/2155-9899.1000502