Journal of Drug Metabolism & Toxicology
Open Access

Ngeranwa JN Joseph

Publications

• Review Article
  A Review of the Biochemical, Hematological and Histological Modulations in Acetaminophen Induced Hepatoxicity and the Potential of Urtica Dioica in the Regeneration of the Liver
  Author(s): Kelvin K Juma, Ngeranwa JN Joseph and Mburu N David Kelvin K Juma, Ngeranwa JN Joseph and Mburu N David
  
  Acetaminophen is a common antipyretic/analgesic drug available as an over the counter prescription. It is an acetilide and phenacetic derivatives. Extensive studies on the safety of acetaminophen have been performed and evidence of hepatoxicity remains to be established. It has also been used in the management of fever and pain. In addition, it has been compounded with many other drugs raising concerns over the safety and efficacy of the use of acetaminophen. The toxicity effect of acetaminophen have also been sustained in all routes of administration; intravenous, intramuscular, rectal and oral with similar biochemical, hematological and histological profiles. The liver is the main organ responsible for metabolic biotransformation of acetaminophen. The hematological, biochemical and pathological effect of the acetaminophen hepatotoxicity will provide a better understanding of the mechan.. View More»
  DOI: 10.4172/2157-7609.1000182

  Abstract PDF

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