Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Nicholas D. Stafford
United Kingdom
Research Article
Frequency Over Function: Raised Levels of CD127low/- Regulatory T cells in the Tumour Microenvironment Compared with the Periphery of Head and Neck Cancer Patients
Author(s): Samantha Drennan, Nicholas D. Stafford, John Greenman and Victoria L. GreenSamantha Drennan, Nicholas D. Stafford, John Greenman and Victoria L. Green
Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response. However, their immunosuppressive function remains poorly understood within the tumour microenvironment and this study aimed to address this.Methods: The frequency and suppressive capacity of two CD4+CD127low/- Treg populations, separated on the basis of different levels of CD25 expression (CD25inter and CD25high), from the tumour/node microenvironment and peripheral circulation of newly-presenting head and neck squamous cell carcinoma patients (n=19), were assessed using multicolour flow cytometry.Results: The proportion of Tregs (CD4+CD25hi.. View More»
DOI:
10.4172/2155-9899.1000241