Biochemistry & Pharmacology: Open Access
Open Access

Nicole Mortensen

Publications

• Research Article
  Pharmacokinetics of Molecular Imprinted Hydrogels as Drug Delivery Vehicles
  Author(s): Patrick Nichols, Nicole Mortensen, Dallin Tingy, Antonio Vasquez and Jeff Bates Patrick Nichols, Nicole Mortensen, Dallin Tingy, Antonio Vasquez and Jeff Bates
  
  Molecular imprinted hydrogels can be made to have a high affinity for a certain compound or drug. A hydrogel can be loaded with a drug and upon a swelling action induced by a pH change or hydration process, the matrix can swell and release the drug. Our hydrogels mimic contact lenses for the purposes of ocular drug delivery. Our hydrogels were imprinted and tested with a prostaglandin derivative, bimatoprost used in the treatment for glaucoma. Major problems preventing entrance to clinical use are bioavailability and drug release kinetics. Our lenses were made to overcome these issues, and were tested for efficacy. The gels were synthesized and were tested to establish a clinically relevant drug delivery profile. Using UV-Vis Spectrophotometry we analyzed the drug released from the gels before, and after cycling. They show a desired and consistent dose release, and a kinetic profile t.. View More»
  DOI: 10.4172/2167-0501.1000238

  Abstract PDF

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