Internal Medicine: Open Access
Open Access

Nikolaos Spanakis

Publications

• Research Article
  Lack of Association of Human Herpesvirus 6 (hHV-6) with Chronic Lymphocytic Leukemia and Leukemic Low-Grade B-Cell Lymphomas
  Author(s): Panagiotis Diamantopoulos, Christina-Nefeli Kontandreopoulou, Theodoros Vassilakopoulos, Maria Angelopoulou, Marina Mantzourani, Nora-Athina Viniou, Nikolaos Spanakis and Athanasios Galanopoulos Panagiotis Diamantopoulos, Christina-Nefeli Kontandreopoulou, Theodoros Vassilakopoulos, Maria Angelopoulou, Marina Mantzourani, Nora-Athina Viniou, Nikolaos Spanakis and Athanasios Galanopoulos
  
  Background: The oncogenicity of Human Herpesvirus 6 (HHV-6) is a matter of continuous interest and several studies have tried to define its pathogenetic role in malignancy with conflicting results. Patients and Methods: We investigated the presence of HHV-6 DNA in peripheral blood samples of patients with immune-phenotypically confirmed chronic lymphocytic leukemia and low-grade B-cell lymphomas by quantitative real-time PCR for the U57 gene of the virus. Results: None out of 48 patients was found positive for HHV-6 (CLL, 60.4%; splenic marginal zone lymphoma, 25.0%; hairy cell leukemia, 4.2%; mantle cell lymphoma, 8.3%; follicular lymphoma, 2.1%). Conclusion: The seroprevalence and PCR detection rate of HHV-6 is relatively high in healthy individuals. This is the lowest percentage of HHV-6 DNA de.. View More»
  DOI: 10.4172/2165-8048.1000273

  Abstract PDF

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