Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Nikolay A. Spiridonov
Center for Drug Evaluation and Research, US Food and Drug Administration,
Bldg. 29A, Rm. 2B-06, 29 Lincoln Drive, Bethesda, MD 20892
Tanzania
Research Article
Mechanisms of Action of Herbal Cholagogues
Author(s): Nikolay A. SpiridonovNikolay A. Spiridonov
Plant secondary metabolic compounds with the cholagogue mode of action are important therapeutic agents for the treatment of cholestasis and hepatobiliary disorders. Herbal cholagogues target different components of the complex bile production and secretion system, and exert their action via diverse routes, such as cholecystokinin-dependent and independent gallbladder contraction, up-regulation of the bile acid synthesis, stimulation of the bile salt export pump, multidrug resistance protein transporter system, and osmotic bile flow.
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DOI:
10.4172/2167-0412.1000107