Journal of Genetic Syndromes & Gene Therapy
Open Access
ISSN: ISSN: 2157-7412
+44 1223 790975
ISSN: ISSN: 2157-7412
+44 1223 790975
Nikolsky NN
Serbia
Research Article
Further Characteristics of Pregnant ?one Marrow Cells Action on Rat Development during Early Pregnancy
Author(s): Mikhailov VM, Sokolova AV, Skripkina NS, Kaminskaya EV, Domnina AP and Nikolsky NNMikhailov VM, Sokolova AV, Skripkina NS, Kaminskaya EV, Domnina AP and Nikolsky NN
There were early results that effect of single intravenous transplantation of pregnant rats Percoll derived mononuclear bone marrow cells (BMC) suspention of 4-5, 7-9 or 11-12 pregnant days to rats with the same date of pregnancy depends on gestation period of transplantation. The weight of 18th day fetuses after intravenous transplantation during 7-9 days was increased with significant difference in comparison with weight of normal fetuses. In case of intravenous BMC transplantation during placentation at 11-12 days of pregnancy the weight of fetuses was decreased, the weight of placentas was increased and survival of fetuses was disturbed. There are several explanations of increase of weight of fetuses after intravenous BMC transplantation within gastrulation including paracrine effect of allogenic transplanted cells on the DC development, the apoptosis and proliferation of embryona.. View More»
DOI:
10.4172/2157-7412.1000316