Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Nilofer Qureshi
Tanzania
Research Article
Suppression of Nitric Oxide Production and Cardiovascular Risk Factors in Healthy Seniors and Hypercholesterolemic Subjects by a Combination of Polyphenols and Vitamins
Author(s): Asaf A. Qureshi, Dilshad A. Khan, Wajiha Mahjabeen, Christopher J. Papasian, and Nilofer QureshiAsaf A. Qureshi, Dilshad A. Khan, Wajiha Mahjabeen, Christopher J. Papasian, and Nilofer Qureshi
Background: Dysregulated immune function associated with ageing has been implicated in a variety of human diseases. We have demonstrated the anti-inflammatory properties of resveratrol, pterostilbene, morin hydrate, quercetin, δ-tocotrienol, riboflavin in a variety of experimental animal models, and determined that these compounds act by inhibiting proteasome activity. Aims: To determine whether serum nitric oxide (NO) levels increase with age in humans, and whether the combined cholesterol-lowering and inflammation-reducing properties of resveratrol, pterostilbene, Morin hydrate, quercetin, δ-tocotrienol, riboflavin, and nicotinic acid would reduce cardiovascular risk factors in humans when used as nutritional supplements with, or without, other dietary changes. Methods: Elderly human subjects were stratified in.. View More»
DOI:
10.4172/2155-9880.S5-008