Clinical & Experimental Cardiology
Open Access

Nilofer Qureshi

Publications

• Research Article
  Evaluation of Pharmacokinetics, and Bioavailability of Higher Doses of Tocotrienols in Healthy Fed Humans
  Author(s): Asaf A Qureshi*, Dilshad A Khan, Neerupma Silswal, Shahid Saleem, and Nilofer Qureshi Asaf A Qureshi*, Dilshad A Khan, Neerupma Silswal, Shahid Saleem, and Nilofer Qureshi
  
  Background: Tocotrienols has been known to lower serum lipid parameters below 500 mg/d, while increase lipid parameters at higher dose of 750 mg/d. δ-Tocotrienol has a novel inflammatory property of concentration-dependent inhibition and activation. Therefore, inhibition (anti-inflammatory) property of tocotrienols at low doses is useful for cardiovascular disease, whereas, activation (pro-inflammatory) property using high dose is found effective for treatments of various types of cancer. We have recently described plasma bioavailability of 125 mg/d, 250 mg/d and 500/d mg doses of δ-tocotrienol in healthy fed subjects, which showed dose-dependent increases in area under the curve (AUC) and maximum concentration (Cmax). Hence, in the current study, higher doses of tocotrienols have used to analyze its effect on plasma pharmacokinetic parameters. .. View More»
  DOI: 10.4172/2155-9880.1000434

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