Clinical & Experimental Cardiology
Open Access

Nilofer Qureshi

Publications

• Research Article
  Impact of δ-Tocotrienol on Inflammatory Biomarkers and Oxidative Stress in Hypercholesterolemic Subjects
  Author(s): Asaf A Qureshi, Dilshad A Khan, Wajiha Mahjabeen, Anne M Trias, Neerupama Silswal and Nilofer Qureshi Asaf A Qureshi, Dilshad A Khan, Wajiha Mahjabeen, Anne M Trias, Neerupama Silswal and Nilofer Qureshi
  
  Background: Tocotrienols have hypocholesterolemic, anti-inflammatory, and anti-cancer properties. Clinical studies using tocotrienol-rich fraction (TRF) from palm oil yielded inconsistent results with regards to its efficacy due to presence of tocopherols in TRF mixture. Objectives: The impact of tocopherol-free δ-tocotrienol on inflammatory and oxidative stress biomarkers, plasma cytokines/proteins, their gene expression, and microRNAs was studied in hypercholesterolemic subjects. Design: Hypercholesterolemic (n=31; serum cholesterol >5.2 mmol/L) subjects were enrolled in the study. All hypercholesterolemic subjects were given increasing doses of δ-tocotrienol (125, 250, 500, 750 mg/d) plus AHA Step-1 diet for 4 weeks each during a 30 week study period. Serum nitric oxide (NO), C-reactive protein (C.. View More»
  DOI: 10.4172/2155-9880.1000367

  Abstract PDF

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