Rheumatology: Current Research
Open Access

Ning Li

Publications

• Research Article
  Development of a Composite Outcome Measure for Systemic Sclerosis Related Interstitial Lung Disease
  Author(s): Elizabeth R Volkmann, Donald P Tashkin, Ning Li, Daniel E Furst, Philip J Clements and Robert M Elashoff Elizabeth R Volkmann, Donald P Tashkin, Ning Li, Daniel E Furst, Philip J Clements and Robert M Elashoff
  
  Objective: While systemic sclerosis-related interstitial lung disease (SSc-ILD) trials predominantly use forced vital capacity (FVC) as the primary outcome, combining individual outcomes may lead to a more comprehensive measure of treatment response and minimize the risk of type 1 error. The present analysis aimed to develop a composite outcome measure to assess treatment response in SSc-ILD patients. Methods: We used data from the Scleroderma Lung Study I (SLS-I) to create the composite outcome measure. SLS I was a multi-institutional, double-blind clinical trial, in which 158 patients with SSc-ILD were randomized to receive either oral cyclophosphamide (CYC) (titrated to 2.0 mg/kg once daily) or matching placebo for one year. To select the variables for inclusion in the composite outcome, we first performed a univariate analysis using all .. View More»
  DOI: 10.4172/2161-1149.1000154

  Abstract PDF

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