Journal of Drug Metabolism & Toxicology
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Njagi ENM

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• Research Article
  The Hypoglycemic Activity and Safety of Aqueous Stem Bark Extracts of Acacia nilotica
  Author(s): Abdirahman YA, Juma KK, Mukundi MJ, Gitahi SM, Agyirifo DS, Ngugi PM, Gathumbi PK, Ngeranwa JJN and Njagi ENMAbdirahman YA, Juma KK, Mukundi MJ, Gitahi SM, Agyirifo DS, Ngugi PM, Gathumbi PK, Ngeranwa JJN and Njagi ENM
  
  Acacia nilotica is used traditionally to manage several diseases including Diabetes mellitus, however, its efficacy and safety is not well evaluated. The aim of this study was to determine in vivo the hypoglycemic activity and safety of the aqueous stem bark extracts of this plant in male swiss white albino mice. The anti-diabetic activity was screened in alloxan induced diabetic mice using oral and intra-peritoneal routes. The safety of this plant extract was studied in mice that were orally and intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording changes in body and organ weight, hematological and biochemical parameters and histology. Mineral composition was estimated using total reflection X-ray fluorescence system and atomic absorption spectrometry. Phytochemical composition was assessed using standard procedures. The extract administered at 50, 10.. View More»
  DOI: 10.4172/2157-7609.1000189

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