Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Noah Isakov
The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences,
P.O.B. 653, Beer Sheva 84105
Israel
Review Article
PKCθ is a Key Regulator of T-cell Behavior and a Drug Target for T cell-mediated Diseases
Author(s): Noah IsakovNoah Isakov
The protein kinase C-theta (PKCθ) isoform is a member of the calcium-independent novel PKC subfamily of serine/threonine kinases. It is an essential regulatory enzyme in mature T lymphocytes, where it plays a key role in coupling the activated TCR and the CD28 costimulatory receptor to their downstream signaling pathways. TCR/ CD28 engagement induces the translocation of PKCθ to the center of the immunological synapse where it undergoes posttranslational modifications and becomes fully active. The activated PKCθ then initiates signaling pathways leading to the activation of transcription factors, including NF-κB, AP-1 and NF-AT that are essential for the survival, activation and differentiation of T cells. While PKCθ ablation was found to impair a wide range of in vitro responses of T cells, in vivo studies in Prkcq-/- mice revealed that distinct T cell subpop.. View More»
DOI:
10.4172/2155-9899.S12-008