Journal of Developing Drugs
Open Access

Norbert Müller

Publications

• Research Article
  Escherichia Coli are Susceptible to Thiazolides If the Tolc Efflux System is Inhibited
  Author(s): Joachim M, Jathana V, Judah LR and Norbert M Joachim M, Jathana V, Judah LR and Norbert M
  
  Nitazoxanide (NTZ) and other thiazolides are effective against intracellular protozoa’s, anaerobic or micro aerophilic bacteria, viruses and tumour cells. Concerning their potential effects against Escherichia coli, the published results are scarce and conflicting. In order to investigate whether thiazolides are effective against aerobically growing E. coli, we examined mutants of the TolC efflux system for their sensitivity to nitro thiazolides, including NTZ, and bromothiazolides. We determined the susceptibilities of tolC mutants to various thiazolides and found that tolC mutants of E. coli were susceptible to both nitro thiazolides and bromothiazolides indicating a mechanism of action different from nitro reduction. Moreover, we showed that thiazolides induced a spy:lacZ transcriptional fusion indicating that thiazolides generate stress in the bacterial envelope. Moreover, w.. View More»
  DOI: 10.4172/2329-6631.1000124

  Abstract PDF

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