Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Noritaka Oyama
Southern Tohoku General Hospital,
Koriyama
Japan
Research Article
Possible Dual Immunoreactivity for Laminin-332 and Type VII Collagen in a Case with Vancomycin-Induced Linear Iga Bullous Dermatosis Manifesting as Erythroderma
Author(s): Yuko Asoh, Noritaka Oyama, Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto and Minoru Yoneda
Yuko Asoh, Noritaka Oyama, Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto and Minoru Yoneda
We report a unique case of vancomycin-induced linear IgA bullous dermatosis (LABD) presenting as erythroderma. Direct immunofluorescence showed a linear IgA deposition at the dermal side of the basement membrane zone (BMZ), and double immunostaining using patients’ skin as a substrate revealed that the in vivo IgA signal co-localized with laminin-332 and type VII collagen. Our case is the first documentation of vancomycin-induced LABD, in which the pathogenic IgA deposit would concomitantly recognize the two distinct antigens at the dermal BMZ.
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DOI:
10.4172/2155-9554.1000151