Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Nurettin Deniz
Turkey
Research Article
Ocular Hemodynamic Response to Intravitreal Pegaptanib in Eyes with Exudative Age-Related Macular Degeneration
Author(s): Burak Turgut, Murat Kaya, Sonay Coskun, Orhan Aydemir and Nurettin DenizBurak Turgut, Murat Kaya, Sonay Coskun, Orhan Aydemir and Nurettin Deniz
Purpose: To assess ocular hemodynamic response to intravitreal pegaptanib in patients with age related macular degeneration (AMD).Methods: Both eyes of twenty patients with choroidal neovascular membrane of at least four MPS (Macular Photocoagulation Study) disc area in one eye due to AMD were undergoing ocular hemodynamic evaluation. Blood flow velocities of both eyes were measured by Color Doppler Ultrasonography (CDU) before and at first, fourth weeks after intravitreal pegaptanib injection and calculated the arterial resistivity indices. The Wilcoxon-signed rank test was used for statistical analysis. Results: In the treated eyes, the mean PSV (Peak Systolic Velocity) of OA (Ophthalmic Artery) increased significantly to a value of 45.37 ± 17.92 at the first (p=0.007), then returned to an insignifi cant value of 4.. View More»
DOI:
10.4172/2155-9570.1000109