Anatomy & Physiology: Current Research
Open Access

Odigie OM

Publications

• Research Article
  Membrane Stabilizing Effects of Calcium in Salt-induced Hypertensive Pregnancy
  Author(s): Aigbiremolen AA, Odigie OM, Iribhogbe IO and Aloamaka CP Aigbiremolen AA, Odigie OM, Iribhogbe IO and Aloamaka CP
  
  Though Calcium is involved in the mechanisms of increase contractility, it has been shown that at high concentration, calcium ions may cause membrane stabilization in which case the smooth muscle responsiveness decreases. Theoretically, a decrease in membrane permeability to calcium ions caused by increased extracellular calcium concentration stabilizes membranes. Apparently, administration of high level of calcium ion may become useful either by way of preventing or diminishing pregnancy induced hypertension (preeclampsia). The goal of this study was to examine the effect of calcium ion on the sensitivity of blood vessels during pregnancy, especially in salt induced hypertensive pregnancy. The isolated aorta of Forty adult Sprague Dawley rats [four groups of ten rats each; with Group 1=non pregnant fed with normal rat chow, Group 2=normal rat chow + 5% CaCl2 prior to and during 6 wee.. View More»
  DOI: 10.4172/2161-0940.1000294

  Abstract PDF

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