Anatomy & Physiology: Current Research
Open Access

Odigie OM

Publications

• Research Article
  Mitigations in Selected Haemostatic Parameters in Administration of Graded Doses of Dexamethasone and its Blockers in Wister Rats
  Author(s): Nwangwa EK and Odigie OM Nwangwa EK and Odigie OM
  
  Clinical trials have shown that an even newer compound, dexamethasone (Dex), might be more potent and less likely to cause side-effects than any other known corticosteroid medication. This study investigated the possible changes in selected haemostatic parameters [clotting time, bleeding time, platelets count and fibrinogen level] in albino wistar rats, following administration of graded doses of Dex. Forty-two male albino Wistar rats were randomly grouped into seven of six rats each. With Group A receiving normal diets (Control), Groups B-G were respectively given 0.1 mg/Kg of Dex, 0.3 mg/Kg of Dex, 0.1 mg/Kg of Dex +33 mg/Kg of Ketokonazol (Keto), 0.3 mg/Kg of Dex +33 mg/Kg of Keto, 0.1 mg/Kg of Dex+Vitamin (Vit) E and 0.1 mg/Kg of Dex. +Vit E. following two-weeks administration period, rats were euthanized and blood samples obtained by cardiac puncture under diethyl ether to determ.. View More»
  DOI: 10.4172/2161-0940.1000297

  Abstract PDF

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