Journal of Alcoholism & Drug Dependence
Open Access

Ohl FW

Publications

• Research Article
  Electrical Stimulation of the Nucleus Accumbens Shell Reduces Voluntary Ethanol Consumption in Bulbectomized Rats
  Author(s): Knape C, Wetzel W, Peters B, Ohl FW and Becker A Knape C, Wetzel W, Peters B, Ohl FW and Becker A
  
  Background: Alcoholism is often accompanied by depression. It has been shown that deep electrical stimulation of the nucleus accumbens is effective in the treatment of alcoholism. Objective: Despite the promising results of clinical trials, the mechanisms underlying its effects are still unclear. To elucidate these mechanisms, valid animal models are needed. Methods: We investigated the effects of electrical stimulation of the nucleus accumbens shell (NAS) and nucleus accumbens core (NAC) on alcohol intake in bulbectomized rats. Bilateral removal of the olfactory bulbs (OBX) is considered a valid animal model of depression. Results: It was shown that electrical stimulation of the NAS with the described stimulus parameters significantly reduced voluntary ethanol intake in OBX rats. After the cessation of stimulation, this effect became insignificant. I.. View More»
  DOI: 10.4172/2329-6488.1000210

  Abstract PDF

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