Cell & Developmental Biology
Open Access

Ojo Abiodun Ayodele4

Publications

• Research Article
  VDR Potentiation and NMDA R Inhibition Facilitates Axo-Dendritic Process Formation in Melanocyte Model for Pigmented Cells in Parkinsonism
  Author(s): Ogundele Olalekan Michael, Ajonijebu, Duyilemi Chris, Okunnuga Adedotun Adetokunbo, Adekeye Adeshina Oloruntoba and Ojo Abiodun Ayodele Ogundele Olalekan Michael, Ajonijebu, Duyilemi Chris, Okunnuga Adedotun Adetokunbo, Adekeye Adeshina Oloruntoba and Ojo Abiodun Ayodele
  
  Background: A major cellular change in dopaminergic neurons leading to Parkinsonism is the alteration of microtubule proteins that causes accumulation of tau protein, α-syn and β-amyloid plaque in the cells. In this study we investigate the role of Vitamin D3 in relieving the symptoms of Parkinsonism as it is capable of stimulating polymerization of microtubules. The Microtubules (MT) system in the fish scale melanocytes has been modeled for the dopaminergic neurons of the Substantia Nigra (SN). These cells are capable of forming cellular processes similar to what is seen in the dopaminergic neurons; in this study, we investigate the protective effect of Vitamin D3 Receptor Agonist (VDRA) and N-Methyl-D-Aspartate Receptor (NMDA R) inhibition in process formation, synaptic denervation and melanin loss in fish scale melanocytes modeled as pigmented adrenergic cells. .. View More»
  DOI: 10.4172/2168-9296.1000127

  Abstract PDF

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