Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Olfa Abida
Tunisia
Research Article
Genetic Factors Contributing to Systemic Lupus Erythematosus in Tunisian Patients
Author(s): Hajer Fourati, Dorra Bouzid, Olfa Abida, Najla Kharrat, Sameh Marzouk, Samy Haddouk, Constantin Fesel, João Costa, Mourad Ben Ayed, Zouhair Bahloul, Carlos Penha-Gonçalves, Ahmed Rebai and Hatem MasmoudiHajer Fourati, Dorra Bouzid, Olfa Abida, Najla Kharrat, Sameh Marzouk, Samy Haddouk, Constantin Fesel, João Costa, Mourad Ben Ayed, Zouhair Bahloul, Carlos Penha-Gonçalves, Ahmed Rebai and Hatem Masmoudi
Systematic lupus erythematosus (SLE) is a multi system autoimmune disease characterized by autoantibodies production, multi-organ damage and complex genetic inheritance. Multiple genetic and environemental factors contribute to the pathogenesis of this disease. Recent genome-wide studies, have added substantially to the number of genes associated with SLE. We performed a case control study using 138 SNPs in 93 Tunisian patients affected with lupus and 162 healthy controls. All SNPs were genotyped in a Sequenom platform. To confirm some associations, associated SNPs were analyzed using logistic regression which allows the test of association with a given SNP by adjusting for the effect of confounding variables. Association was especially reported with rs3733197 (P=0.0026, OR=2.04), rs17266594 (P=0.046, OR=1.56) in BANK1 gene, rs2070197 (P=0.0016, OR=2.31), rs2004640 (P=0.024, OR=1.54),.. View More»
DOI:
10.4172/2155-9899.1000129