Angiology: Open Access
Open Access

Olga A Bercovich

Publications

• Research Article
  L162v Polymorphism of Peroxisome Proliferator-activated Receptor-alpha Gene and Markers of Immune Inflammation in Patients with Coronary Artery Disease
  Author(s): Elena G Sergeeva, Olga A Bercovich, Michail A Carpenko, Zhanna I Ionova and Anna A KostarevaElena G Sergeeva, Olga A Bercovich, Michail A Carpenko, Zhanna I Ionova and Anna A Kostareva
  
  New risk factors for coronary artery disease (CAD) have been identified recently – mediators of immune inflammation. Peroxisome proliferator-activated receptors alpha (PPAR-α) belong to nuclear receptors superfamily and regulate the activity of different genes coding the factors of immune inflammation. The goal of this study is to determine the association of L162V polymorphism of PPAR-α gene with factors of immune inflammation and the risk of coronary artery disease development in Russian population. The current study included 424 patients with coronary artery disease (359 men and 65 women) aged 33 to 80 years (mean age- 61,6 ± 0,48 years). The control group consisted of 220 people without CAD of comparable age (mean age- 60,09 ± 0,72 years, p = 0.081). Polymerase chain reaction and restriction analysis were performed. IL-6, interferon-gamma .. View More»
  DOI: 10.4172/2329-9495.1000177

  Abstract PDF

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