Journal of Clinical & Experimental Dermatology Research
Open Access

Olga Martínez Sáez

Publications

• Case Report
  Toxicoderma Secondary to 5-Fluorouracil: Differential Diagnosis of Paraneoplastic Pemphigus
  Author(s): Olga Martínez-Sáez, Eva Hermosa-Zarza, Alfredo Carrato and Reyes Ferreiro Monteagudo Olga Martínez-Sáez, Eva Hermosa-Zarza, Alfredo Carrato and Reyes Ferreiro Monteagudo
  
  We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence of circulating antibodies supports the diagnosis. In our case, the anatomopathological and immunological findings and the clinical improvement after the suspension of 5-FU confirmed that it was toxicoderma secondary to the latter. .. View More»
  DOI: 10.4172/2155-9554.1000396

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