Journal of Leukemia
Open Access

Oliver Bock

Publications

• Review Article
  The Current Molecular Site of the Myeloproliferative Neoplasms - TET-á-tête with the Jackpot but no LNK so far to Resolve Complexity
  Author(s): Oliver Bock Oliver Bock
  
  The myeloproliferative neoplasms essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are clonal haematological stem cell disorders with different clinical courses and prognosis. The predominant feature in these entities is the overproduction of at least one cellular lineage in the bone marrow. Peripheral blood cells are terminally differentiated and functional but may affect e.g. blood viscosity with a high hematocrit in PV leading to the risk for thrombotic events or bleeding. PMF, preceded by a hypercellular pre-fibrotic stage, has the highest risk to develop manifest bone marrow fibrosis with consecutive bone marrow failure. The risk for a blast crisis and transformation into secondary acute leukemia is also particularly high in PMF and PV but rather uncommon in ET. Even though distinguishable from each other by clinical and histopathological criteri.. View More»
  

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