Endocrinology & Metabolic Syndrome
Open Access

Olopade JO

Publications

• Research Article
  Implication of Hongres1 Protein in Quassin-Induced Male Reproductive Abnormality in Rats
  Author(s): Obembe OO, Olopade JO and Raji YObembe OO, Olopade JO and Raji Y
  
  Objective: Quassin, the bioactive constituent of Quassia amara plant, has been reported to decrease sperm count, sperm motility, normal sperm morphology and male fertility index. These sperm characteristics are however acquired in the epididyimis. Information on the effects of quassin on epididymal functions is scanty. The effects of quassin on epididymal functions were therefore investigated in Wistar albino rats. Methods: Quassin (0.1 and 2 mg/kg) and distilled water (0.5 ml) were administered by gavage (p. o) daily for 6 weeks to male rats (180-200 g, n=5), and thereafter sacrificed. Sperm motility, viability and count were examined microscopically. Serum from each rat was analyzed for Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Testosterone by enzyme immunoassay technique. Alanine Aminotransferase (ALT), Aspartate Amin.. View More»
  DOI: 10.4172/2161-1017.1000128

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