Journal of Clinical Toxicology
Open Access

Osano KO

Publications

• Review Article
  Biochemical Markers of In Vivo Hepatotoxicity
  Author(s): Arika WM, Nyamai DW, Osano KO, Ngugi MP and Njagi ENM Arika WM, Nyamai DW, Osano KO, Ngugi MP and Njagi ENM
  
  A chemical compound, whether of natural or of synthetic origin, brings about a toxicological effect when its dose is high enough or the duration of exposure is sufficient to cause an alteration in the normal homeostasis of body fluids and tissues. Therefore, the right dose differentiates a toxicant from a remedy. The body detoxifies drugs and other chemical compounds through key organs such as the liver. The liver plays a central role in the metabolism and excretion of xenobiotics which makes it highly susceptible to their adverse and toxic effects. These effects can be manifested in the form of hepatic injuries, which take many forms from cellular degeneration and necrosis to cirrhosis or cholestasis to vascular injury. Exposure to hepatotoxicants alters the homeostatic balance of various biological markers that provides a powerful and dynamic approach to understanding the spectrum o.. View More»
  DOI: 10.4172/2161-0495.1000297

  Abstract PDF

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