Immunotherapy: Open Access
Open Access

Oxana V. Klimenko

Publications

• Research Article
  Joint Action of the Nano-sized System of Small Non-coding RNAs with DDMC Vector and Recombinant IL-7 Reprograms A-549 Lung Adenocarcinoma Cells into CD4⁺ Cells
  Author(s): Oxana V. Klimenko* Oxana V. Klimenko*
  
  Small non-coding RNAs, as class of small regulatory molecules, control normal development and differentiation of cells. Micro-RNAs and piwi-interacting-RNAs are members of epigenetic regulators family. In previous studies researches investigated the role of different small non-coding RNAs in pathophysiology of cancer. Objective: In this study A-549 lung adenocarcinoma cells were firstly epigenetically reprogrammed and transformed into CD4+ cells. Method: I used new non-viral carrier the complex of DDMC vector with antago-miR-155 and piR-30074 for long-lasting transfection of lung cancer cells. Results: The transformation of A-549 lung cancer cells was proved by morphological and genetic changes (AltAnalyze Platform) in dynamics. I observed CD4+ lymphocytes phenotypic marker and OCT4 .. View More»
  DOI: 10.4172/2471-9552.1000137

  Abstract PDF

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