Journal of Proteomics & Bioinformatics
Open Access

Padchanee Sangthong

Publications

• Research Article
  Human Urinary GM2-activator Protein as a Potential Biomarker for Lung Cancer
  Author(s): Laddawan Potprommanee, Haou-Tzong Ma, Chein-Hung Chen, Paitoon Aobchey, Kongsak Boonyapranai, Busyamas Chewaskulyong, Padchanee Sangthong, Lalida Shank and Shui-Tein ChenLaddawan Potprommanee, Haou-Tzong Ma, Chein-Hung Chen, Paitoon Aobchey, Kongsak Boonyapranai, Busyamas Chewaskulyong, Padchanee Sangthong, Lalida Shank and Shui-Tein Chen
  
  Human urine can be obtained from most patients by noninvasive ways of collection. It is a rich source of biomarkers for diagnostic tests, therapeutic guidance and prognostic information for patients and clinicians. Recently, the protein expression pattern of urine samples from lung cancer patients and healthy controls were compared using two-dimensional gel electrophoresis (2-DE). GM2 activator protein (GM2AP) in lung cancer patients with 2.5-4.0 folds higher than that found in healthy controls was the protein of interest, and this protein was focused because it is related to tumor-associated gangliosides found in cancer progression. The aim of this study was to investigate the urinary biomarkers associated with lung cancer. First, we applied proteomic approach to confirm the increase level of GM2AP in urine samples from lung cancer patients and healthy controls. Then, the expression .. View More»
  DOI: 10.4172/jpb.1000289

  Abstract PDF

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