Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Palash Mandal
Biological Sciences, P.D. Patel Institure of Applied Sciences,
Changa, Anand-388421, Gujarat
India
Review Article
Association of Advanced Glycation End Products (AGEs) with Diabetic Nephropathy and Alcohol Consumption
Author(s): Kirti Parwani, Palash Mandal
Kirti Parwani, Palash Mandal
The occurrence of diabetes is accelerating worldwide, with consequent increase in the secondary complication like diabetic nephropathy (DN). Diabetic nephropathy refers to a set of structural and functional abnormalities of kidney in patients with diabetes. Detrimental changes like glomerular hypertrophy, glomerulosclerosis, hyperfiltration, proteinuria, etc. occur in DN. One of the major pathways suggested for the pathogenesis is formation of Advanced Glycation End Products (AGEs) via non enzymatic glycation (NEG). NEG is the process in which reducing sugars irreversibly modify free amino groups of proteins, by various events leading to the formation of a Schiff base resulting in Amadori products, culminating into AGEs. AGEs activate several cascades of intracellular signaling via interaction with Receptor for AGEs (RAGE) that results in responses like release of pro-inflammatory cyt.. View More»
DOI:
10.4172/2329-6488.1000290