Reproductive System & Sexual Disorders: Current Research
Open Access

Pamela J. Murray

Publications

• Research Article
  Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men
  Author(s): Sachin V. Bendre, Pamela J. Murray and Shehzad Basaria Sachin V. Bendre, Pamela J. Murray and Shehzad Basaria
  
  Background: Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while preventing testicular atrophy. No studies to date using CC have been done in younger obese post-pubertal hypogonadal males. Objective: To determine whether CC therapy is effective in increasing serum T levels in hypogonadal post-pubertal obese males 18-21 years. Materials and Methods: A retrospective chart analysis of records in obese men aged 18-21 years was done. Patients with early morning T level <350 ng/dl were given 25 mg .. View More»
  DOI: 10.4172/2161-038X.1000155

  Abstract PDF

Relevant Topics