Journal of Proteomics & Bioinformatics
Open Access

Parthasarathy Satishchandra

Publications

• Research Article
  Transcriptomic Profiling of Medial Temporal Lobe Epilepsy
  Author(s): Abhilash K. Venugopal, Ghantasala S. Sameer Kumar, Anita Mahadevan, Lakshmi Dhevi N. Selvan, Arivusudar Marimuthu, Jyoti Bajpai Dikshit, Pramila Tata, Ramachandra YL, Raghothama Chaerkady, Sanjib Sinha, Chandramouli BA, Arivazhagan A, Parthasarathy Satishchandra, Shankar SK and Akhilesh PandeyAbhilash K. Venugopal, Ghantasala S. Sameer Kumar, Anita Mahadevan, Lakshmi Dhevi N. Selvan, Arivusudar Marimuthu, Jyoti Bajpai Dikshit, Pramila Tata, Ramachandra YL, Raghothama Chaerkady, Sanjib Sinha, Chandramouli BA, Arivazhagan A, Parthasarathy Satishchandra, Shankar SK and Akhilesh Pandey
  
  Epilepsy is one of the most prevalent neurological disorders affecting ~1% of the population. Medial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy observed in adults who do not respond to pharmacological treatment. The reason for intractability in these patients has not been systematically studied. Further, no markers are available that can predict the subset of patients who will not respond to pharmacotherapy. To identify potential biomarkers of epileptogenicity, we compared the mRNA profiles of surgically resected tissue from seizure zones with non-seizure zones from cases of intractable MTLE. We identified 413 genes that exhibited ≥ 2-fold change that were statistically significant across these two groups. Several of these differentially expressed genes have not been previously described in the context of MTLE including claudin 11 ( CLDN11 ) and bo.. View More»
  DOI: 10.4172/jpb.1000210

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