Journal of Clinical and Experimental Ophthalmology
Open Access

Parul Saxena

Publications

• Research Article
  Expression of p53 and Mdm2 in Human Retinoblastoma
  Author(s): Parul Saxena, Seema Kashyap, Mandeep Singh Bajaj, Neelam Pushker, Supriyo Ghose and Jasbir KaurParul Saxena, Seema Kashyap, Mandeep Singh Bajaj, Neelam Pushker, Supriyo Ghose and Jasbir Kaur
  
  Retinoblastoma (Rb) is a malignant tumor of the developing retina. Retinoblastomas arise within the retina to form soft white tumor masses that expand within the vitreous cavity of the eye, and if untreated, mostly invade through the sclera, or along the optic nerve, or hematogenously via the choroids, in turn posing a risk for metastasis. However, it is an uncommon tumor accounting for 3% of all childhood malignancies in developed countries. Very few studies on p53 expression in retinoblastoma patient’s inspite of its crucial role in tumorigenesis are officially recorded. Therefore, we detected the expression of p53 and mdm2 in retinoblastoma by immunohistochemistry, analyzed their relationships with clinicopathological parameters and then investigated the influence on the biological activity of retinoblastoma... View More»
  

  Abstract PDF

Relevant Topics