Anatomy & Physiology: Current Research
Open Access

Patel A

Publications

• Review Article
  Does the Role of Angiogenesis Play a Role in Atherosclerosis and Plaque Instability?
  Author(s): Patel APatel A
  
  Atherosclerosis is an inflammatory vascular disease which begins as fatty streaks underlining the endothelium of large artery walls, usually coronary or carotid. It consists of endothelial dysfunction, the accumulation of lipid and cholesterol in the intima from a young age and the recruitment of inflammatory cells to sites of damage in the artery wall. The disease progresses through several stages, eventually resulting in the formation of a cholesterol rich plaque. The role of angiogenesis in atherosclerosis has been of growing interest over the last 20 years since experimental studies have not been able to support a causal relation. Angiogenesis involves hyperplasia of the vasa vasorum in the early stages of atherosclerosis which is thought to be angiogenesis independent, followed by intimal neovascularization in the late angiogenesis dependent stages of the disease. Angiogenesis in.. View More»
  DOI: 10.4172/2161-0940.1000147

  Abstract PDF

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