ISSN: 2167-0412
+44 1300 500008
Patsaki Anastasia
Doukissis Plakentias 10 Athens,
11523
Greece
Research Article
The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats
Author(s): Patsaki Anastasia, Job Tchoumtchoua, Christina Passali, Lelovas Pavlos, Stavros Kourkoulis, Nikolaos Papaioannou, Jean-Claude Mbanya, Dieudonné Njamen, Sofia Mitakou, Maria Halabalaki and Ismene Dontas
Patsaki Anastasia, Job Tchoumtchoua, Christina Passali, Lelovas Pavlos, Stavros Kourkoulis, Nikolaos Papaioannou, Jean-Claude Mbanya, Dieudonné Njamen, Sofia Mitakou, Maria Halabalaki and Ismene Dontas
Background: To assess the potential phytoestrogenic effect of Amphimas pterocarpoides plant extract on the ovariectomy (OVX) induced bone loss in rats. Methods: Thirty nine female (10 month old) Wistar rats were separated into Controls (n=11), OVX (n=13) and OVX+AP groups (n=15). Measurements of Bone Mineral Density (BMD) were performed at baseline, 3 and 6 months after ovariectomy. After 6 months treatment, the rats were euthanized and femurs were extracted. The biomechanical properties were evaluated using the 3-point bending test. Results: The percentage changes of the mean values of the proximal tibia BMD from baseline to 3 months for Control, OVX and OVX+AP group were 6.25%, -21.82% and - 12.73% whereas at 6 months they were 8.108%, -32.134% and -22.410% respectively. The 3-point bending test revealed that the maximal load before fracture and the mean values for stress significan.. View More»
DOI:
10.4172/2167-0412.1000269