Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Pattabhiraman Lalitha
Malaysia
Research Article
CART Assignment of Folding Mechanisms to Homodimers with Known Structures
Author(s): Abishek Suresh, Pattabhiraman Lalitha and Pandjassarame KangueaneAbishek Suresh, Pattabhiraman Lalitha and Pandjassarame Kangueane
Protein homodimers play a critical role in catalysis and regulation and their mechanism of folding is intriguing. The mechanisms of homodimer folding (2-state [2S] without intermediates and 3-state [3S] with either monomer [3SMI] or dimer [3SDI] intermediates) have been observed and documented for about 46 homodimers (27 2S; 12 3SMI; 7 3SDI) with known 3D structures. Determination of folding mechanisms through classical denaturation experiments is both time consuming, tedious, and expensive. Therefore, it is of interest to predict their folding mechanism. Furthermore, a large number of homodimers structures with unknown folding mechanism are available in the PDB. Hence, it is compelling to predict their folding mechanism using structural features intrinsic of each complex structure. Thus, we developed a classi fi cation and regression tree (CART) model .. View More»
DOI:
10.4172/jpb.1000152