Immunome Research
Open Access

Paul A Gatenby

Publications

• Review Article
  The Role of Environmental Factors in the Pathogenesis of Anti-Neutrophil Antibody Associated Vasculitis
  
  Author(s): Paul A GatenbyPaul A Gatenby
  
  This review seeks to critically examine the environmental factors reported to be associated with anti-neutrophil antibody associated systemic vasculitis. The published literature was searched in a systematic fashion. From this emerges strong evidence for a latitude gradient in the case of granulomatous polyangiitis and eosinophilic granulomatous polyangiitis; both appear more common at high latitudes. Microscopic polyangiitis does not demonstrate this. Latitude affects ultraviolet radiation exposure and the relationship of increased incidence of granulomatous polyangiitis and eosinophilic polyangiitis with decreased ultraviolet radiation exposure is much stronger. The most plausible explanation is vitamin D levels, a hormone known to be vital for normal immune function and largely synthesised in humans secondary to ultraviolet radiation exposure. Case control studies demonstrate a con.. View More»
  DOI: 10.4172/1745-7580.1000073

  Abstract

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