Journal of Clinical & Experimental Dermatology Research
Open Access

Paula Aguilera

Publications

• Research Article
  Clinical and Histopathological Characteristics between Familial and Sporadic Melanoma in Barcelona, Spain
  Author(s): Paula Aguilera, Josep Malvehy, Cristina Carrera, Josep Palou, Joan Anton Puig-Butillé, Llúcia Alòs, Celia Badenas, Susana PuigPaula Aguilera, Josep Malvehy, Cristina Carrera, Josep Palou, Joan Anton Puig-Butillé, Llúcia Alòs, Celia Badenas, Susana Puig
  
  Background: About 6 to 14% of melanoma cases occur in a familial setting. Germline mutations in CDKN2A are detected in 20 to 40% of melanoma families. Objective: To characterise the clinical and histopathological characteristics of familial melanoma thus providing more information to clinicians and contribute to the understanding of the genetic-environment interplay in the pathogenesis of melanoma. Methods: Clinical, histological and immunohistochemical characteristics of 62 familial melanomas were compared with 127 sporadic melanomas. Results: variables associated with familial melanoma were earlier age at diagnosis (OR 1.036; 95% CI 1.017- 1.055), lower Breslow thickness (OR 1.2.. View More»
  DOI: 10.4172/2155-9554.1000231

  Abstract PDF

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