Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Paula Sá
Portugal
Research Article
Oxygen Increases Lung Inflammatory Response in Spontaneous One-Lung Ventilation in Rabbits: A Prospective Randomized Experimental Study
Author(s): Humberto S Machado, Catarina S Nunes, Paula Sá, António Couceiro, Álvaro Moreira da Silva and Artur ÁguasHumberto S Machado, Catarina S Nunes, Paula Sá, António Couceiro, Álvaro Moreira da Silva and Artur Águas
Study objective: The purpose of this study was to investigate if oxygen supplementation would increase lung inflammatory response in a spontaneous one-lung ventilation animal model, when compared to room-air oxygen fraction. Design: In vivo prospective randomized animal study Setting: University research laboratory Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 2 groups (n=10 each group). Groups (OS – Oxygen Supplemented, and NOS – Non-Oxygen Supplemented) were submitted to spontaneous One-Lung Ventilation (OLV) during 60 minutes; OS group had a 2-liter/minute oxygen supplement, and NOS group was kept on roomair. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into interpleural space, and left lung collapse was visually confirmed through the cen.. View More»
DOI:
10.4172/2155-6148.1000489