ISSN: 2155-6148
+44 1223 790975
Per Blom
Sweden
Research Article
Nitrous Oxide Self-Administered from a Demand Valve for 4-Minute Period: Dose-Effect on Attention, Mode and Wakefulness
Author(s): Per Blom, Michael H. Silverman, Roy S. Fishman and Jan G. JakobssonPer Blom, Michael H. Silverman, Roy S. Fishman and Jan G. Jakobsson
Nitrous oxide is unique in that it is none-invasive and has a rapid onset of action, making it a valuable option in a variety of emergent situation and in painful paediatric procedures. The present randomised controlled study was set up in order to explore the effects of 3 different concentrations of nitrous oxide, 40, 55 and 70 vol. % as compared to placebo, provided by self administered from a demand valve by healthy volunteers for a short 4-minute period evaluating effect on attention, mode and wakefulness. Onset time and peak reduction in attention, change in saccadic eye movements, showed a dose dependent pattern. After brief use, saccadic eye movements returned to baseline within minutes after cessation of administration. Loss of consciousness was observed only during administration of the 70 vol. %, minor side effects such as dizziness and nausea was observed during inhalation .. View More»
DOI:
10.4172/2155-6148.1000126