Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Peter D Burrows
Tanzania
Review Article
Susceptibility Loci in C57BL/6 sle1, sle2 and sle3 Contain Genes that Alter Peripheral Selection of the CDR-H3 Sequences Enriched for Arginine
Author(s): Mohamed Khass, Peter D Burrows and Harry W Schroeder
Mohamed Khass, Peter D Burrows and Harry W Schroeder
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by deposition of ds- DNA binding autoantibodies in various body organs. These antibodies result from failure to control the composition of the B cell repertoire. Development of optimum B cell repertoire depends on the amino acid composition and the physicochemical characteristics at the center of the antigen binding site, the third complementarity determining region heavy chain (CDR-H3). Repertoire control involves positive selection for hydrophilic amino acids such as tyrosine and negative selection of hydrophobic and charged amino acids, specifically those containing arginine within the CDR-H3. Anti-dsDNA antibodies present in SLE patients exist in healthy individuals but at low levels, since dsDNA-specific B cells are deleted from the repertoire, but amplified in SLE patients. These antibodies c.. View More»
DOI:
10.4172/2155-9899.1000544