Journal of Clinical Toxicology
Open Access

Peter J Syapin

Publications

• Research Article
  Alcohol-induced Bone Loss and Quality during Adolescence is Improved by Green Tea Polyphenols
  Author(s): Chwan-Li Shen, Peter J Syapin, Jennifer L Graef, Brenda J Smith, Gordon Brackee, Anna Kate Fowler, Ismael Segura-Ulate, Jia-Sheng Wang and Susan E BergesonChwan-Li Shen, Peter J Syapin, Jennifer L Graef, Brenda J Smith, Gordon Brackee, Anna Kate Fowler, Ismael Segura-Ulate, Jia-Sheng Wang and Susan E Bergeson
  
  Our previous studies have shown significant osteo-protective effects of green tea polyphenols (GTP, green tea extract) in various bone loss models. To test the hypothesis that green tea supplementation would protect against binge alcohol-induced deterioration of bone quality in adolescent drinkers, we used a similar approach with green tea supplementation in drinking water. Using a six week, 2 × 3 factorial design of treatment × dose in male Sprague Dawley (SD) adolescent rats, bone parameters [femoral and lumbar vertebrae-4 (LV-4) area (BMA), bone mineral content (BMC), bone mineral density (BMD)], bone turnover biomarkers [serum osteocalcein (OC) and tartrateresistant acid phosphatase-5b (TRAP-5b)] and blood chemistry were measured. The blood chemistry results showed that alcohol administration significantly decreased albumin, glucose, alkaline phosphatase, and amylase l.. View More»
  DOI: 10.4172/2161-0495.S7-004

  Abstract PDF

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