Journal of Drug Metabolism & Toxicology
Open Access

Philip D Glaves

Publications

• Short Article
  The Post-Transcriptional Regulator EIF2S3 and Gender Differences in the Dog: Implications for Drug Development, Drug Efficacy and Safety Profiles
  Author(s): Tamara J Nicolson, Philip D Glaves and Ruth RA RobertsTamara J Nicolson, Philip D Glaves and Ruth RA Roberts
  
  Canis familiaris, the domestic dog, is a key animal species for preclinical drug development, including toxicity assessment. As data relating to gender dimorphic toxicity in the clinic emerge, the topic of sex differences in relation to drug toxicity will increase in prominence. Much of the emerging clinical data cannot easily be explained by body weight or body fat differences – hence the gender differences may be related to more complex hormonal and/or potential underlying gene expression differences. The dog also demonstrates some gender differences in drug-induced toxicity; hence, in the current study, we investigated differences at the gene expression level between male and female dogs in selected tissues of relevance to toxicity. We attempted to elucidate whether key gene expression differences do exist and if so, whether these gender differences may potentially impact on .. View More»
  DOI: 10.4172/2157-7609.1000101

  Abstract PDF

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