Journal of Tumor Research
Open Access
ISSN: 2684-1258
ISSN: 2684-1258
Piercarlo Sarzi-Puttini
Italy
Research Article
Immunoglobulin M Distribution and Modular Peptide Interactions in the Stroma of Human Colorectal Adenomas and Adenocarcinomas
Author(s): Caterina Defendenti, Fabiola Atzeni, Sandro Ardizzone, Paolo Declich, Simone Saibeni, Emanuela Nebuloni, Simona Bollani, Savino Bruno, Valeria Lucini, Piero Luigi Almasio and Piercarlo Sarzi-PuttiniCaterina Defendenti, Fabiola Atzeni, Sandro Ardizzone, Paolo Declich, Simone Saibeni, Emanuela Nebuloni, Simona Bollani, Savino Bruno, Valeria Lucini, Piero Luigi Almasio and Piercarlo Sarzi-Puttini
Background: Tissue organisation field theory explains that cancer starts as a result of an alteration in supporting tissue and inflammatory cells. The immunoglobulins (Igs) detected in colorectal adenocarcinomas come from the loss of integrity of resident μ chain-producing cells. Nearly half of the contact residues of Igs are aromatic and highly reactive. In the same way, the vast majority of cell surface proteins in the extra-cellular matrix contain a number of different domains or modules. The (Arg-Gly-Asp) RGD receptor domain of fibronectin constitutes cell adhesion receptors for cell-matrix adhesion and for bidirectional signaling across the membrane. Highly homologous oligopeptides emulate and compete with matrix adhesive proteins: Streptavidin binds to cells via the (Arg-Tyr- Asp) RYD mimetic RGD peptide. Furthermore, tyrosine-tryptophan-threonine-aspartic ac.. View More»
DOI:
10.35248/2684-1258.17.3.133