Translational Medicine
Open Access

Pinchen Yang

Publications

• Research Article
  A Pilot Open-Label Trial of Use of the Glycine Transporter I Inhibitor, Sarcosine, in High-Functioning Children with Autistic Disorder
  Author(s): Pinchen Yang, Hsien-Yuan Lane, Cheng-Fang Yen, Chen-Lin Chang Pinchen Yang, Hsien-Yuan Lane, Cheng-Fang Yen, Chen-Lin Chang
  
  This open-label trial examined the efficacy and safety of a glycine transporter I inhibitor, sarcosine, in the 24-week treatment of high-functioning children with autistic disorder. Four children (three boys, one girl, 9-11 years of age; average intelligence quotient 80.5) completed the 24 weeks of study. Sarcosine administration was at 30 mg/kg/day in the form of a capsule in two divided doses. The outcome measures were. Autism Diagnostic Observation Schedule (Module 3), parent and teacher-reported Adaptive Behavior Assessment System-II, parenting stress index, Conners’ Continuous Performance Test, Wisconsin Card Sorting Test, child behavior checklist and Swanson, Nolan and Pelham IV hyperactivity attention scales. Safety assessments included monthly recorded vital signs, body weight, body height and adverse events. Statistical analysis found no significant treatment effect on .. View More»
  DOI: 10.4172/2161-1025.1000127

  Abstract PDF

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