Immunome Research
Open Access
ISSN: 1745-7580
+44-77-2385-9429
ISSN: 1745-7580
+44-77-2385-9429
Polona Žigon
Immunology laboratory,
University Medical Centre, Ljubljana
Slovenia
Research Article
The Prevalence and Clinical Significance of Iga Anti-Phosphatidylserine/
Prothrombin Antibodies in Systemic Autoimmune Diseases
Author(s): Polona Žigon, Aleš Ambrožič, Polonca Mali, Matija Tomšič, Snežna Sodin Šemrl and Saša ČučnikPolona Žigon, Aleš Ambrožič, Polonca Mali, Matija Tomšič, Snežna Sodin Šemrl and Saša Čučnik
Objective: Studies on antiphospholipid antibodies have mainly focused on the IgG and IgM isotypes, with only a few investigating the pathogenic significance of IgA antiphospholipid antibodies. Positive IgA anticardiolipin (aCL) and IgA anti-β2 glycoprotein I (anti-β2GPI) were reported to be predominantly associated with other antiphospholipid antibodies, making it difficult to understand the role of IgA alone. Recently, antibodies against phosphatidylserine/ prothrombin (aPS/PT) IgG and IgM have been indicated as a potential marker for antiphospholipid syndrome (APS). Our previous study reported that IgG and IgM aPS/PT showed highest association with lupus anticoagulant (LA) activity of all tested antiphospholipid antibodies, while no studies to date have investigated possible clinical benefits of IgA aPS/PT. In this study, we determined the prevalence of Ig.. View More»
DOI:
10.4172/1745-7580.10000130